* Top aging expert says these 4 FDA-approved drugs hold promise for extending life, PDF paper, Gerotherapy:
** GLP-1 receptor agonist - calorie restriction
semaglutide (Ozempic, Wegovy) Novo Nordisk
tirzpatide (Mounjaro, Zepbound) Eli Lilly
** SGLT2 inhibitors to remove sugar from the kidneys through urine
empagliflozin (Jardiance) Boehringer Ingelheim
** Bisphosphonates - osteoporosis
** Metformin - insulin sensitivity
- AgelessRx Longevity Products Metformin, Rapamycin, NAD+, Galleri Multi-Cancer Early Detection Test, Microdosing GLP-1
Fountain Life Diagnostics Full-Body/Brain MRI, Coronary CT Angiography, Low Dose Lung CT scan
Neko Health not MRI/CT scan
Collagen $0.85/20g serving, Creatine 肌酸 $0.12/5g serving, Whey protein 24g protein (6g Branched-chain amino acid BCAA)/32g serving, $10/1lb,
* 2024/07 A primer on the current state of longevity research: sirtuins - NAD+ (NMN, NR, resveratrol, fisetin, quercetin), cellular reprogramming, biological clocks (grip strength, graying hair, wrinkled skin, epigenetic: Horvath's clock, telomere, transcriptomics, proteomics)
* 2024 Scientists find humans age dramatically in two bursts – at 44, then 60 The first wave of changes included molecules linked to cardiovascular disease and the ability to metabolise caffeine, alcohol and lipids. The second wave of changes included molecules involved in immune regulation, carbohydrate metabolism and kidney function.
* 2024 Massive biomolecular shifts occur in our 40s and 60s, Stanford Medicine researchers find, Nonlinear dynamics of multi-omics profiles during human aging, In people in their 40s, significant changes were seen in the number of molecules related to alcohol, caffeine and lipid metabolism; cardiovascular disease; and skin and muscle. In those in their 60s, changes were related to carbohydrate and caffeine metabolism, immune regulation, kidney function, cardiovascular disease, and skin and muscle.
* 2019 Undulating changes in human plasma proteome profiles across the lifespan 34, 60, 78
Centenarian blood tests give hints of the secrets to longevity: glucose, creatinine, uric acid, cholesterol, iron, TIBC, liver (Alat, Asat, albumin, GGT, Alp, LD)
Beyond Resveratrol: The Anti-Aging NAD Fad
Star research team maps nr and nmn conversion path to cellular nad
Nicotinamide riboside (NR), ChromaDex Niagen (about niagen) Truniagen, Elysium Health (Basis), HPN Niagen, Life Extension NAD+ Cell Regenerator, with Resveratrol grape skin, red wine Pinot Noir
Nicotinamide mononucleotide (NMN/菸醯胺單核苷酸 500mg), The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule (liposomal NMN), Scientists identify new fuel-delivery route for cells, David Sinclair, Human trials of NMN therapy, Alive by Nature
Pterostilbene Resveratrol Elysium Basis
Sex and the Supplements: Dietary Supplement Ingredients for Male Sexual Health, Tongkat Ali, Fenugreek, HPN
Pterostilbene, Resveratrol, Jarrow
