NAD+

* Top aging expert says these 4 FDA-approved drugs hold promise for extending life, PDF paper, Gerotherapy: 

** GLP-1 receptor agonist - calorie restriction 

     semaglutide (Ozempic, Wegovy) Novo Nordisk 

     tirzpatide (Mounjaro, Zepbound) Eli Lilly 

** SGLT2 inhibitors to remove sugar from the kidneys through urine 

     empagliflozin (Jardiance) Boehringer Ingelheim 

** Bisphosphonates - osteoporosis 

** Metformin - insulin sensitivity 

- AgelessRx Longevity Products Metformin, Rapamycin, NAD+, Galleri Multi-Cancer Early Detection Test, Microdosing GLP-1 

Fountain Life Diagnostics Full-Body/Brain MRI, Coronary CT Angiography, Low Dose Lung CT scan 

Neko Health not MRI/CT scan 

Collagen $0.85/20g serving, Creatine 肌酸 $0.12/5g serving, Whey protein 24g protein (6g Branched-chain amino acid BCAA)/32g serving, $10/1lb, 

* 2025/06 repost A primer on the current state of longevity research sirtuin (NAD), 

* 2024/07 A primer on the current state of longevity research: sirtuins - NAD+ (NMN, NR, resveratrol, fisetin, quercetin), cellular reprogramming, biological clocks (grip strength, graying hair, wrinkled skin, epigenetic: Horvath's clock, telomere, transcriptomics, proteomics) 

* 2024 Scientists find humans age dramatically in two bursts – at 44, then 60 The first wave of changes included molecules linked to cardiovascular disease and the ability to metabolise caffeine, alcohol and lipids. The second wave of changes included molecules involved in immune regulation, carbohydrate metabolism and kidney function.  

* 2024 Massive biomolecular shifts occur in our 40s and 60s, Stanford Medicine researchers find, Nonlinear dynamics of multi-omics profiles during human aging, In people in their 40s, significant changes were seen in the number of molecules related to alcohol, caffeine and lipid metabolism; cardiovascular disease; and skin and muscle. In those in their 60s, changes were related to carbohydrate and caffeine metabolism, immune regulation, kidney function, cardiovascular disease, and skin and muscle. 

* 2019 Undulating changes in human plasma proteome profiles across the lifespan 34, 60, 78 

Centenarian blood tests give hints of the secrets to longevity: glucose, creatinine, uric acid, cholesterol, iron, TIBC, liver (Alat, Asat, albumin, GGT, Alp, LD) 

Nicotinamide adenine dinucleotide NAD 
Beyond Resveratrol: The Anti-Aging NAD Fad 
Star research team maps nr and nmn conversion path to cellular nad 

Nicotinamide riboside (NR), ChromaDex Niagen (about niagen) Truniagen, Elysium Health (Basis), HPN Niagen, Life Extension NAD+ Cell Regenerator, with Resveratrol grape skin, red wine Pinot Noir 

Nicotinamide mononucleotide (NMN/菸醯胺單核苷酸 500mg), The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule (liposomal NMN), Scientists identify new fuel-delivery route for cells, David Sinclair, Human trials of NMN therapy, Alive by Nature 

Pterostilbene Resveratrol Elysium Basis

Sex and the Supplements: Dietary Supplement Ingredients for Male Sexual Health, Tongkat Ali, Fenugreek, HPN

Pterostilbene, Resveratrol, Jarrow 

7/25/2023 The Best Biological Age Tests Of 2023 + 10 Factors That Impact Longevity

6/23/2023 Why Is Everyone Obsessed With Biological Age?

3/2/2023 How old are YOU really? AI-powered tests reveal your biological age with a simple cheek swab - and tell you how to slow it down

11/18/2022 I found out my biological age—and was annoyed by the result

8/29/2022 Want to Know Your Biological Age? Buyer Beware.

6/13/2022 Real age versus biological age: the startups revealing how old we really are

1/5/2022 For 2022, Here’s What Startups Are Doing To Extend Our Lifespans