ALZ Clinical Trials Phase III Taiwan
221AD301 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease (ENGAGE) Biogen
Biogen predicts preventive drug for Alzheimer’s disease
新藥減緩認知衰退 治阿茲海默症重燃希望
Controversy Surrounds Biogen and Eisai’s Alzheimer’s Drug Aducanumab
3. A Study of LY3314814 in Participants With Mild Alzheimer's Disease Dementia (DAYBREAK-ALZ) Eli Lilly
FDA Approved:
6/7/2021 Aduhelm (aducanumab) - Biogen Eisai
1/6/2023 Leqembi (lecanemab-irmb) Eisai Biogen 7/6/2023 traditional approval
1/6/2023 Leqembi (lecanemab-irmb) Eisai Biogen 7/6/2023 traditional approval
oligomannate GV-971 九期一 甘露特钠胶囊
阿尔茨海默症新药难在哪 阿杜卡奴抗体 aducanumab 渤健 卫材
Changhua, Kaohsiung Medical University, Kaohsiung Chang Gung, National Cheng Kung, National Taiwan University, Chang Gung
National Institute on Aging: Alzheimer's Disease Research Centers
Treating Alzheimer's > Cognitive Symptoms
Bredesen Protocol
藥物治療 - 阿茲海默症
* Alzheimers disease alternative treatments
Caprylic acid - coconet oil
* Omega-3 fatty acid. Polyunsaturated fat Fatty acid ratio in food, good ω-3: flaxseed (low smoking point, rancid easily)
Changhua, Kaohsiung Medical University, Kaohsiung Chang Gung, National Cheng Kung, National Taiwan University, Chang Gung
National Institute on Aging: Alzheimer's Disease Research Centers
Treating Alzheimer's > Cognitive Symptoms
Bredesen Protocol
Three cholinesterase inhibitors are commonly prescribed:
- donepezil (Aricept), which is approved to treat all stages of Alzheimer’s disease 2006
- rivastigmine (Exelon), approved for mild to moderate Alzheimer’s 2007
- galantamine (approved in 2001 under the trade name Reminyl and renamed Razadyne in 2005), also approved for mild to moderate stages
How are cholinesterase inhibitors used?
- Donepezil (Aricept®) is a tablet and can be administered once daily. Generally, the initial dose is 5 mg a day(usually given at night). After four to six weeks, if it is well tolerated, the dose is often increased to the therapeutic goal of 10 mg a day.
- Rivastigmine (Exelon®) is available as patch, a capsule or as a liquid. The dosage is gradually increased to minimize side effects. Usually the medication is started at 1.5 mg daily. After two weeks the dosage is increased to 1.5 mg twice a day. The therapeutic goal is to increase the dosage gradually every two weeks to reach 6 to 12 mg a day given in two doses, each equal to half the total. There is a greater frequency of side effects at these higher doses; however, taking drugs with meals may be helpful in reducing the occurrence of side effects.
- Galantamine (Razadyne) is supplied as tablets in strengths of 4, 8 and 12 mg. The recommended starting dose is 4 mg twice a day. If well tolerated after four weeks or more of treatment, the dose is increased to 8 mg twice a day. There was no statistical benefit in clinical trials for 12 mg twice a day over the dose of 8 mg twice a day, but if 8 mg twice a day is well tolerated after four weeks, the dose can be increased to 12 mg twice a day by the physician. Galantamine is also available in an “extended release” form as Razadyne ER that is designed to be taken once a day.
藥物治療 - 阿茲海默症
| 膽鹼酶抑制劑: | 愛憶欣(Aricept, donepezil)、憶思能（Exelon,rivastigmine）、利憶靈（Reminyl, galantamine）。可能的副作用有噁心、拉肚子、厭食、頭痛、嘔吐等。 |
* Alzheimers disease alternative treatments
Caprylic acid - coconet oil
* Omega-3 fatty acid. Polyunsaturated fat Fatty acid ratio in food, good ω-3: flaxseed (low smoking point, rancid easily)
* low ω-6 (linoleic), high linoleic acid ratio wrecking gut health (olive, avocado, high-oleic safflower, flaxseed)
* low Omega-6/Omega-3 ratio: canned fish in water, Vegetable oil linseed/flaxseed 亞麻籽油, Canola rapeseed oil 菜籽油和芥花油
* Omega-9 Oleic acid monounsaturated good for high temperature: high-oleic safflower, olive, avocado (high smoke point), canola (high bad ω-6)
- Are seed oils really as harmful as Robert F. Kennedy Jr. claims? The Myth of the Bad Seed Oil. 多數人吃的油是化學油？ Seed oil misinformation Hexane 己烷 sesame, peanut, tea seed, olive, cold-pressed avocado, Expeller pressing high temperature vs cold-pressed
- Seed Oil Free Certified: avocado, cocoa, coconut, olive, palm fruit/kernel. Low-concern seed oils high-oleic seed oils, low omega-6 (linoleic): almond, argan, brazil nut, cashew, chia seed, hazelnut, hemp seed, high-oleic safflower/soybean/sunflower, macadamia, pecan, pine nut, pistachio, poppy, pumpkin, sesame, walnut
- animal fat: lard, tallow, butter
* Phosphatidylserine
* Phosphatidylserine
- Rancidification rancid
1997 A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Moderate stage: Vitamin-E (Alpha-Tocopherol) 2000IU
Dietary Supplement Fact Sheet: Vitamin E Tolerable Upper Intake Levels 1500 IU
1997 A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Moderate stage: Vitamin-E (Alpha-Tocopherol) 2000IU
Dietary Supplement Fact Sheet: Vitamin E Tolerable Upper Intake Levels 1500 IU
臺裔科學家蔡立慧研發阿茲海默聲光刺激療法！臨床2期顯著延緩記憶、認知退化、腦萎縮-環球生技月刊 - Cognito Therapeutics Announces Positive Phase 2 Results as First Digital Therapeutic to Improve Memory, Cognition, Functional Abilities and Reduce Brain Atrophy in Alzheimer’s Disease - Small studies of 40-hertz sensory stimulation confirm safety, suggest Alzheimer’s benefits - Sensory Stimulation Detoxifies the Alzheimer’s Brain 40-Hz sound and light oscillations activate neural waste-disposal action - Delta 台達M+護智燈
