Tuesday, April 15, 2008

DNA tests

reddit 23andme V5
Imputation Analysis Utilizing Promethease
free:
GEDmatch
DNA.LAND 
Codegen.eu 
low cost:
Promethease

Which tools can be used to analyze 23andMe raw data?
What Else Can I Do With My DNA Test Results? (free and fee)
Autosomal DNA tools (health/risk)
23andyou third party tools

Codegen.eu
Sequencing.com
Cure Together 

What $2500 Can Buy in DNA Services
Navigenics offers direct consumer DNA tests
Enter Navigenics, Where Personal Genomics Gets More Medical
May We Scan Your Genome?
GPPC Calls for Improved Oversight of PGx Dxs After Uncovering Inconsistent Marketing

Best Cat DNA Test: Understand Your Feline’s Health and Diet Needs, Basepaws, HomeDNA, Optimal Selection
UC Davis Veterinary Genetics Laboratory. Cat Ancestry - Tracing the Lineage of Your Feline

Dopamine
Back-to-School: The Genetics of Learning from Your Mistakes: DRD2 TaqIA rs1800497, AA (A1 Allele), less dopamine receptors, not learning from mistakes
Why You Gave Your Parents a Hard Time Growing Up: ANKK1 rs1800497 AA: lower dopamine D2 receptor, not avoiding stick
Genetics May Dull Brain’s Pleasure Response to Food, Causing Weight Gain: rs1800497, AA fewer dopamine receptors,
Genetic Variant May Increase Risk for Anxiety Disorders: COMT rs4680 AG GG GG AG A: more startled, dopamine stays
DNA Variation May Help Us Break Free From Our Routines: COMT rs4680 AG GG GG AG A: Adventurous more dopamine activity, DRD2 rs6277 GG less dopamine signaling, not avoid NoGo
Next Year It’s Martinelli’s…: rs27072 CC CT CT CC, rs27048 CC withdrawal

Evidence for Gene-Environment Interaction in Alcoholism: rs1799971 AG AA AA AG G: need more morphine Genetic Variation In Morphine Receptor May Play A Part In Coping With Social Rejection, rs1799732 II riskier

Back to School Smarts and Geneticsnon-verbal intelligence, rs363050 GG AA AG AG, A higher IQ

Alcohol dependence

DNA Day
American Society of Human Genetics GenEdNet
National Human Genome Research Institute

The $5000 genome by 2009? Complete Genomics emerges from stealth mode
Complete Genomics
Knome

Promethease is a tool to build a report based on SNPedia and a file of genotypes. Customers of 23andMe, deCODEme, or Navigenics can use it to learn more about their genome.
Tell me Everything: How To Use SNPedia for 23andMe and deCODEme

10 million SNPs in human
Navigenics $999, plus an optional $199 annual subscription fee, 900,000 SNP chip Affymetrix Genome-Wide Human SNP Array 6.0, 18 diseases

23andMe 576,105 snps $999, since 4/2006, 550,000+30,000 different single nucleotide polymorphisms (SNPs) illumina humanhap550+ genotyping beadchip, 58 gene journal, ancestry (maternal, paternal, painting, family inheritance, global similarity)
23andMe v2 10/2008-11/2010 596,532 snps $399, illumina HumanHap550-Quad+ (semi-custom Human610-Quad BeadChip) discount code
23andMe version 3 991,624 snps 11/2010-11/13
23andMe v4 (vs. v3) 598,897 11/13-08/17
23andMe v5 650k snps 08/17

deCODEME deCODE genetics $985, 1 million genomic variations illumina human1M, 26 gene profiles, 2 physical attributes, ancestry (geography, female, male line)
Gene Essence $1195, Affymetrix Genome-wide Human SNP Array 6.0, 90 diseases
DNAdirect $199 and up
Pathway Genomics $348 Health and Ancestry Kit

  * * * Age-related Macular Degeneration
    *   Alcohol Dependence
    * * Alcohol Flush Reaction
  *   * Alzheimer's disease
    *   Ankylosing Spondylitis
    *   Antidepressant Response
      * Asthma
    * * Atrial Fibrillation
    *   Attention-Deficit Hyperactivity Disorder
    *   Avoidance of Errors
    *   Back Pain
    *   Bipolar Disorder
    *   Birth Weight
    * * Bitter Taste Perception
    *   Blood Groups
  * * * Breast Cancer
    *   Caffeine Metabolism
  * * * Celiac Disease
    *   Cluster Headaches
  * * * Colorectal Colon Cancer
  * * * Crohn's Disease
    *   Developmental Dyslexia
    *   Earwax Type
  * * * Exfoliation Glaucoma
    * * Eye Color
    *   Food Preference
    *   Freckling
  *     Graves' Disease
    * * Hair Color
    *   HDL Cholesterol Level
  * * * Heart Attack
    *   Height
      * Hemochromatosis
    *   Heroin Addiction
    *   High Blood Pressure (Hypertension)
    *   HIV/AIDS Infection
    * * Lactose Intolerance
    *   Longevity
    *   Lou Gehrig's Disease (ALS)
      * Lung cancer
  *     Lupus
    *   Malaria Resistance
    *   Male Infertility
    * * Male Pattern Baldness
    *   Measures of Intelligence
    *   Memory
  * * * Multiple Sclerosis
    *   Muscle Performance
      * Nicotine Dependence
  * * * Obesity
    *   Obsessive-Compulsive Disorder
    *   Odor Detection
  *     Osteoathritis
    *   Pain Sensitivity
      * Peripheral Arterial Disease
    *   Persistent Fetal Hemoglobin
    *   Placental Abruption
  * * * Prostate Cancer
  *   * Psoriasis
  * * * Restless Legs Syndrome
  * * * Rheumatoid Arthritis
    *   Tardive Dyskinesia
    * * Type 1 Diabetes
  * * * Type 2 Diabetes
    *   Venous Thromboembolism

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