ALZ Clinical Trials Phase III Taiwan
221AD301 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease (ENGAGE) Biogen
Biogen predicts preventive drug for Alzheimer’s disease
新藥減緩認知衰退 治阿茲海默症重燃希望
Controversy Surrounds Biogen and Eisai’s Alzheimer’s Drug Aducanumab
3. A Study of LY3314814 in Participants With Mild Alzheimer's Disease Dementia (DAYBREAK-ALZ) Eli Lilly
FDA Approved:
6/7/2021 Aduhelm (aducanumab) - Biogen Eisai
1/6/2023 Leqembi (lecanemab-irmb) Eisai Biogen 7/6/2023 traditional approval
1/6/2023 Leqembi (lecanemab-irmb) Eisai Biogen 7/6/2023 traditional approval
oligomannate GV-971 九期一 甘露特钠胶囊
阿尔茨海默症新药难在哪 阿杜卡奴抗体 aducanumab 渤健 卫材
Changhua, Kaohsiung Medical University, Kaohsiung Chang Gung, National Cheng Kung, National Taiwan University, Chang Gung
National Institute on Aging: Alzheimer's Disease Research Centers
Treating Alzheimer's > Cognitive Symptoms
Bredesen Protocol
藥物治療 - 阿茲海默症
* Alzheimers disease alternative treatments
Caprylic acid - coconet oil
Omega-3
* Phosphatidylserine
1997 A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Moderate stage: Vitamin-E (Alpha-Tocopherol) 2000IU
Dietary Supplement Fact Sheet: Vitamin E Tolerable Upper Intake Levels 1500 IU
Changhua, Kaohsiung Medical University, Kaohsiung Chang Gung, National Cheng Kung, National Taiwan University, Chang Gung
National Institute on Aging: Alzheimer's Disease Research Centers
Treating Alzheimer's > Cognitive Symptoms
Bredesen Protocol
Three cholinesterase inhibitors are commonly prescribed:
- donepezil (Aricept), which is approved to treat all stages of Alzheimer’s disease 2006
- rivastigmine (Exelon), approved for mild to moderate Alzheimer’s 2007
- galantamine (approved in 2001 under the trade name Reminyl and renamed Razadyne in 2005), also approved for mild to moderate stages
How are cholinesterase inhibitors used?
- Donepezil (Aricept®) is a tablet and can be administered once daily. Generally, the initial dose is 5 mg a day(usually given at night). After four to six weeks, if it is well tolerated, the dose is often increased to the therapeutic goal of 10 mg a day.
- Rivastigmine (Exelon®) is available as patch, a capsule or as a liquid. The dosage is gradually increased to minimize side effects. Usually the medication is started at 1.5 mg daily. After two weeks the dosage is increased to 1.5 mg twice a day. The therapeutic goal is to increase the dosage gradually every two weeks to reach 6 to 12 mg a day given in two doses, each equal to half the total. There is a greater frequency of side effects at these higher doses; however, taking drugs with meals may be helpful in reducing the occurrence of side effects.
- Galantamine (Razadyne) is supplied as tablets in strengths of 4, 8 and 12 mg. The recommended starting dose is 4 mg twice a day. If well tolerated after four weeks or more of treatment, the dose is increased to 8 mg twice a day. There was no statistical benefit in clinical trials for 12 mg twice a day over the dose of 8 mg twice a day, but if 8 mg twice a day is well tolerated after four weeks, the dose can be increased to 12 mg twice a day by the physician. Galantamine is also available in an “extended release” form as Razadyne ER that is designed to be taken once a day.
藥物治療 - 阿茲海默症
| 膽鹼酶抑制劑: | 愛憶欣(Aricept, donepezil)、憶思能（Exelon,rivastigmine）、利憶靈（Reminyl, galantamine）。可能的副作用有噁心、拉肚子、厭食、頭痛、嘔吐等。 |
* Alzheimers disease alternative treatments
Caprylic acid - coconet oil
Omega-3
* Phosphatidylserine
1997 A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Moderate stage: Vitamin-E (Alpha-Tocopherol) 2000IU
Dietary Supplement Fact Sheet: Vitamin E Tolerable Upper Intake Levels 1500 IU
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